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Extracellular nucleosomes and NET-bound histones provide negatively charged surfaces that can activate the contact pathway via factor XII (FXII) autoactivation, while NET-associated tissue factor (TF) and TF-bearing microparticles amplify extrinsic pathway signaling in certain inflammatory contexts [64]

GHK-Cu is posited to possibly boost the expression and nuclear translocation of Nrf2 in lung tissues, thereby promoting the transcription of genes that combat oxidative stress and possibly enhancing the cellular resilience against oxidative damage

Namely, vitamin C has been found to decrease skin aging on both intrinsic and extrinsic levels

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