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Fecal matter from metformin-treated mice attenuates intestinal ferroptosis induced by IIRI To investigate the role of the gut microbiota in the anti-ferroptosis effect of metformin, we established a dirty cage group by allowing mice to feed on metformin-modulated feces from the MET group

Actionable Takeaway In routine visits, document GI symptom burden and QOL impact, avoid ordering direct-to-consumer-style stool microbiome/SCFA tests, and counsel patients to increase dietary fiber and consider adding safe fermented dairy (e.g., yogurt/kefir) if tolerated

Injectable treatments like glutathione are also promising treatment solutions that improve whitening and skin elasticity

Use Vitamin E: Vitamin E also supports skin cell protection and helps glutathione work better in the body