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*Correspondence: Hang Lin, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Tissue Engineering and Regenerative Medicine, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

22,23 Historically, varicocele has been thought to cause infertility by reducing oxygenation and increasing oxidative stress in the testicular environment, but more recent evidence also implicates inflammatory and immune mechanisms

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