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Evidence has been presented that suggests that the phenotypic effect associated with genetic variability in pro- and anti-inflammatory cytokine genes is determined by the presence of specific haplotypes, characterized by the coexistence of specific variants of individual cytokine genes, and not by the genotype of a single locus [112]

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By definition, heterosynaptic plasticity refers to changes at synapses that were not presynaptically activated during the induction protocol (Box 1)