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The most frequently reported adverse effects of tirzepatide are predominantly gastrointestinal in nature, reflecting the medication's mechanism of action on GLP-1 receptors in the digestive system

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Triple-Hormone-Receptor Agonist Retatrutide for Obesity Weekly retatrutide injections (1 mg12 mg) resulted in weight reductions of 7.217.5% at 24 weeks and 8.724.2% at 48 weeks in subjects with overweight or obesity (without T2DM) in a phase II, double-blind, randomized, placebo-controlled [125]