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In young adult mice on a high-fat diet, MOTS-c also activated muscle AMPK and increased GLUT4 levels, leading to better glucose uptake in muscle and prevention of fat accumulation

Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system

Excessive depletion of oxidants may result in the induction of reductive stress, characterized by declined physiological functions, such as suppressed mitochondrial function, cell proliferation, the occurrence of cardiomyopathies, and other pathologies (Rajasekaran et al

The condition may also trigger intestinal inflammation and damage to the epithelial barrier, accelerating the systemic translocation of bacteria-derived uremic toxins