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Therapeutic implications and future directions Currently, the available evidence demonstrates that region-specific BBB dysfunction including reduced CBF (shortfalls and dysregulations), impaired BBB integrity (increased BBB permeability and transport system), and vascular inflammation (extravasated plasma components and peri-vascular inflammatory responses) contributes to the onset and progression of multiple neurodegenerative disorders

Activated microglia produced inflammatory mediators, such as prostaglandin E 2 , interleukin-1 TNF, ROS (peroxideH 2 O 2 , superoxideO 2 ), and reactive species nitrogenous (RNS: NO

H1459H1463, 2013 [29] A

10.15252/msb.20167422 Mol Syst Biol