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(2011) 17 independently demonstrated that N-acetylcysteine amide (NACA) remarkably protected retinal pigmented epithelium (RPE) and photoreceptors against oxidative cell damage and death, in vitro (ARPE-19 cell culture treated with tBHP) and in vivo (light damage mouse model)

Parnham also expressed hesitation about the way Sikiric presented the data, describing him as wielding flashy slides with too much certainty, like a marketing pitch. At the end of 2009, the licensing rights to BPC-157 were returned to Sikiric, along with all of the data that PLIVA had generated

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It directly neutralizes reactive oxygen and nitrogen species, including hydrogen peroxide, superoxide, and peroxynitrite