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In other cell types, arginine synthesis by citrulline is very low but dramatically increases when inducible nitric oxide synthase (NOS) increases (Fig

Gardner, A., Iverson, G

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In an open randomized trial that investigated the step-down approach, 60% of the patients who received a combination of immunosuppressants were in steroid-free remission compared with 35.9% in a conventional step-up treatment group at week 26 (Panaccione et al., 2011)