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Glutathione Depletion: How NYCs Urban Environment Accelerates Antioxidant Loss New York City, while a vibrant hub of activity, exposes its residents to unique environmental and lifestyle stressors that can lead to a hidden deficiency: glutathione depletion

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Both cytosolic and peroxisomal isoforms of Cu/Zn-SOD rely on zinc for stability and activity, and MTs serve as zinc buffers, releasing zinc under oxidative stress to fine-tune redox signaling and enzyme expression 94