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[DOI] [PubMed] [Google Scholar] 168.Andersen J.V., Jakobsen E., Westi E.W., Lie M.E.K., Voss C.M., Aldana B.I., Schousboe A., Wellendorph P., Bak L.K., Pinborg L.H., et al

But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established

A recent publication by Drogue [59, 60], who has extensively investigated the relationship of oxidative stress and aging, has concluded that this event may be in great part be associated with a deficit of cysteine and to a suboptimal intake of SAA

The Bottom Line Theres a clear association between lower B12 levels and a higher body-weight