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J Clin Invest 1992, 90: 21232129

[DOI] [PubMed] [Google Scholar] Schmitt M

According to clinicians, sublingual administration bypasses both the gut and the liver, allowing glutathione to enter the bloodstream in its reduced (active) form, boosting the ratio of GSH to GSSG by 230 per cent, whereas oral glutathione supplementation is either reduced into simple amino acids during digestion or oxidised and hence, no longer stays active when swallowed