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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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It contains methylcobalamin (vitamin B12), pyridoxine (vitamin B6), niacinamide, and D-panthenol, which support the healthy functioning of the brain and nervous system, aid the formation of red blood cells, and help maintain healthy haemoglobin levels