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Thus, to support the validity of our snRNA-seq dataset, we performed untargeted proteomics on the same replicates that were pooled for snRNA-seq

In recent years, increasing attraction has been paid to metabolic network as for cancer cells have the capability to support survival and growth by adopting extensive metabolic rewiring in response to alterations in internal or external circumstances [4, 5]

Among these, L-Cys is the most important precursor, primarily acquired through the glutamate/cysteine antiporter system Xc which plays a key role (Fig