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The copper(II) ion participates in metalloenzyme cofactor functions, including lysyl oxidase (required for collagen cross-linking) and superoxide dismutase (SOD)

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However, proprietary blends obscure most ingredient dosages and make it difficult to truly estimate the chance of side effects from certain riskier nootropic ingredients

Several meta-analyses of observational studies have found elevated blood concentrations of homocysteine to be linked with an increased risk of dementia (74) or Alzheimers disease (68, 75-78)