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Hayashi K, Lopes SM, Tang F, Surani MA (2008)

Health Risks and Side EffectsMisuse of boldenone is associated with a wide range of severe health disorders: Cardiovascular Issues: Risk of heart problems.Liver and Kidney Damage: Potential for hepatic (liver) and renal (kidney) impairment.Reproductive Issues: In males, it can cause decreased natural testosterone production, reduced testes size, lower sperm count, and decreased sperm mobility.Psychological Effects: Can lead to behavioral and neurochemical alterations, including anxiety, aggression, and mood disorders.Carcinogen Classification: It is classified as a probable human carcinogen by the International Agency for Research on Cancer

To our knowledge, dogs with naturally occurring IVD degeneration have not been used, even though it is recognized that CD dog breeds are a suitable animal model of spontaneous IVD degeneration [9, 13]

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