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De fait, il contribue au renforcement des dfenses de lorganisme par son action stimulatrice sur la production de lymphocytes ou dinterleukine du systme immunitaire 22 23

On the other hand, at high concentrations, NO is known to react with superoxide anions (O 2 ) to generate peroxynitrite (ONNO ), which has the potential to accumulate protein aggregates between the RPE and photoreceptors, leading to their degeneration [223,224]

However, accumulating evidence suggests that all LDH isoforms retain the inherent capacity to mediate pyruvate-to-lactate conversion accompanied by NAD+ regeneration, and that LDHA and LDHB can functionally compensate for each other under metabolic stress (44,45)

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