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Cell-penetrating peptides in glioma Regarding the impermeability of the BBB and cell membrane to therapeutic macromolecules (of large size and low permeability), the incorporation of CPPs, which increase the crossing of the BBB and plasma membrane in peptide-based drug delivery systems, can be a clever solution

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Though the results are controversial, as iron nanoparticles have no effect on the microbiota, zinc (Zn)-nanoparticles can have some beneficial effects, and other components such as silicon dioxide (SiO 2 ) nanoparticles may cause IEB disruption