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Therefore, genetic factors such as those can be identified through family history, and other risk factors, including environment pollutions (household and ambient air pollution) and/or epigenetic regulations in response to environmental pollutions, may play important roles in the pathogenesis of COPD in the never-smokers

In a placebo-controlled study where saquinavir or placebo was administered orally as a 1,200 mg dose, three times a day, for 5 days (n=12), a 56% reduction in the clearance of midazolam following a single 0.05 mg/kg IV dose was observed

Archived from the original on April 7, 2018

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