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This reduction of inflammation allows for recovery of the Meibomian glands in both form and function, improves the quality of the tear film, enhances tear film stability, reduces evaporation of the tears from the surface of the eyes, and improves ocular lubrication, thus improving dry eye signs and symptoms

The metabolic inhibitor sodium azide also significantly reduced the cellular uptake of the nanocarriers, suggesting an active cellular process (Fig

These markers included increased plasma alanine and lactate levels and the presence of organic acids, such as 3-methyl-glutaconic and dicarboxylic acids, and Krebs cycle intermediates, in the urine of these patients [69]

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