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Chandys hypothesis is accurate, the initial worsening might be a sign that the body is starting to heal or correct imbalances that have been present for a long time

J Neurosci Res 79 : 734746

578 , 1037 , 1038 , 1039 One analysis assumed a treatment that delayed onset of Alzheimer's by five years would reduce total health and longterm care spending for people with Alzheimer's by 33%, including a 44% reduction in outofpocket payments by 2050, 1037 and another study projected a 14% reduction in total health care spending for people age 70 and older with Alzheimer's from a oneyear delay, a 27% reduction from a threeyear delay, and a 39% reduction from a fiveyear delay by 2050

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3 pathway