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How These Biotypes Work Together A simplified view: Undermethylation low ceruloplasmin copper overload oxidative stress developmental strain and ASD traits These biotypes form a self-reinforcing cycle: Undermethylation increases free copper Free copper amplifies oxidative stress Oxidative stress intensifies undermethylation symptoms All three disrupt neurotransmitters, sensory pathways, and emotional regulation This is why autism cannot be understood through behavior alone