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Biomolecules & Therapeutics, 24 (6), 630-637

Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines, cytokines, chemokines, excess lipids and toxic lipid metabolites promote IR in other tissues

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However, plasticity in some types of interneurons may differ from excitatory cells in its dependence on [Ca 2+ ] i rises (e.g., Camir and Topolnik, 2014) or tetanization frequency (Le Roux et al., 2013) and may follow cell type-specific STDP rules (Lu et al., 2007)