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475 Aberrant and premature developmental gliogenesis (which ultimately affects both neurones and glia) lies at the core of the cellular pathophysiology of Down syndrome

While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

It hits melanocortin receptors a totally separate anti-inflammatory pathway from GHK-Cus NF-B work or BPC-157s growth factor modulation

On the evidence question: The absence of Phase III human trial data for compounds like BPC-157 and TB-500 is a genuine clinical limitation, not a technicality