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Table 47 Severity scores: severity of subcutaneous tissue necrosis and inflammatory cell infiltration 5 days post injection, for co-formulation vehicles varying in HP-B-CD content and molar substitution degree as well as in overall buffer composition Concluding Remarks The results in table 47 show that the in vivo local subcutaneous tolerability depended on the concentration of HP-B-CD and the overall buffer composition

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Passot G, Kim BJ, Glehen O, Mehran RJ, Kopetz SE , Goere D, Overman MJ, Pocard M, Marchal F, Conrad C, Aloia TA, Vauthey JN, Chun YS, Group BW