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The combination of enhanced glycolysis and insulin resistance creates a self-perpetuating cycle of metabolic dysfunction, contributing to disease progression and increasing the risk of type 2 diabetes mellitus in HCV-infected individuals (139)

4,5 Subsequent studies have also detected that lactylation occurs on non-histone proteins, and is classified into enzymatic L-lactylation and non-enzymatic D-lactylation based on the major sources of the lactyl moiety and enzyme involvement, thereby establishing its extensive regulatory potential

Environ Exp Bot 54(2):109120

Rarely, complications such as infection or color changes in the skin may occur