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On the other hand, IRPs combine with the IRE on the transferrin receptor mRNA to stabilize its mRNA, promote the expression of transferrin receptor, and increase iron uptake (Recalcati et al., 2010

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ

10.3748/wjg.v28.i25.2843 [DOI] [PMC free article] [PubMed] [Google Scholar] Alberghina M., Lupo G., La Spina G., Mangiameli A., Gulisano M., Sciotto D., et al