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Synaptic functionality of these synapses was demonstrated via the presence of analog-induced spinogenesis, and the colocalization of synaptic markers in newly formed dendritic spines which were coupled with enhanced miniature excitatory postsynaptic currents

Some voltage-gated ion channels, namely, the potassium (K + ), calcium (Ca 2+ ), and sodium (Na + ) channels, could also be oxidized by ROS to consequently affect DRG neuronal excitability and conduction