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The firstand most importantis that they actually seem to work

Second, long-term safety is a critical consideration for any potential AD treatment, and while our short-term safety evaluation did not reveal any significant adverse effects associated with (-)-Vestitol and Salviolone administration, it is crucial to acknowledge that these findings do not guarantee long-term safety when used chronically for AD treatment

Inhibition of cysteine uptake by p53 can sensitize cells to ferroptosis through downregulating the expression of SLC7A11 and GPX4, reduction of antioxidant capacity, and resultant ROS accumulation [53, 54]

In summary, these studies indirectly demonstrate the antidepressant activity of luteolin (Table 1) [[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37]]