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The supportive research is overwhelmingly preclinical rat and cell-culture studies of the individual peptides, not randomized human trials of the blend

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In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability

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