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NAD+ is crucial as a coenzyme in reactions that generate ATP (energy) in cells, and it also serves as a substrate for enzymes involved in DNA repair and gene regulation

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ASS1 expression has been reported to be decreased or even abolished in many cancers (Dillon et al., 2012), HCC (Delage et al., 2009), which are thought of as arginine-auxotrophic cancers because of the inability to synthesize arginine and resulting susceptibility to arginine-deprivation therapy