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The conversation shifts from 'What unknown thing is causing this problem?' to 'How do we manage the known physiological responses to GH elevation?' That is a world of difference

However, 50% of yeast GRXs are oxidized at resting conditions 59 , supporting our notion that the midpoint redox potential of the active site disulfide does not determine the redox state of GRXs if they are in an environment with the interacting ligands GSH and GSSG

Think of it like loosening a clamp on a pipe flow increases, but the effect is specific to that vascular tissue type and hasnt been shown to generalize beyond it

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