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Acting as a crucial sensor for assessing the nutritional status of eukaryotic cells, mTOR exhibits activation in response to a surplus of amino acid availability, thereby regulating an assortment of synthetic metabolic pathways essential for sustaining cellular growth [157]

Once administeredmost often via subcutaneous injection , but sometimes orally or topicallythese peptides bind to cell surface receptors , initiating a cascade of biological effects

Further, targeted metabolomics results revealed that GGCT knockdown markedly attenuated TCA cycle flux, decreasing key intermediates including pyruvate, succinate and fumarate (Fig

It loses its structural integrity through oxidative damage and inadequate repair signaling