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The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA

A study in rats subjected to IRI showed an increase in the level of PARP1 expression in the renal tubules within 12 h post-reperfusion, and administration of a PARP inhibitor after reperfusion caused an elevated level of ATP, diminished histopathological indication of tubular damage, and improved renal function in this model [142]