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Orange or brown Urine that is orange or brown can be caused by severe dehydration, jaundice or rhabdomyolysis, although some types of medication can also lead to brown urine, such as metronidazole, which is used to treat bacterial infections, or quinine, which is used to treat malaria

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That is the maximum prescribed dose, typically reserved for patients who have been on tirzepatide for five months or longer and have gradually worked their way up through the entire tirzepatide dosing chart