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For mouse lung epithelial (MLE)-12 cells treated with cigarette smoke extract (CSE), Sp1 and SIRT1 levels were low, HIF-1 acetylation levels were high, and cell senescence and secretion of SASP factors were elevated

10.1016/s0022-3565(25)22379-5 172 ShimokawaY.YodaN.KondoS.YamamuraY.TakiguchiY.UmeharaK

He pondered the concept of self-love and what it meant if he was no longer the same husband, father and provider for his family