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Therefore, we sought evidence that in mature human intervertebral discs, matrix disruption and swelling can disturb cell-matrix binding and lead to cell clustering, together with expression of a degenerative cell phenotype

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These mechanisms are observed only in controlled laboratory and animal studies

Compared with standard glutathione (500 mg), LipoMicel at a lower dose (300 mg) increased iAUC and C max by ~2.49-fold and ~2.43-fold, respectively, and when dose-normalized (to a 300 mg equivalent), incremental systemic exposure and peak levels were up to ~4-fold higher, supporting greater absorption per unit dose. The findings indicate LipoMicel is a promising delivery method for oral glutathione, though the researchers added larger, long-term studies are still needed