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Physical barriers (e.g., extracellular matrix, abnormal vasculature, cancer-associated fibroblasts) hinder immune cell infiltration and drug delivery while compromising T cell cytotoxicity

Novel antidepressant-like properties of the iron chelator deferiprone in a mouse model of depression

Boban Blagaic A, Blagaic V, Mirt M, et al

Taken together, the researchers concluded that thyroid function may affect mast cells, and that mast cell degranulation could affect thyroid function.[ref] In patients with autoimmune thyroid disease, mast cells infiltrate the thyroid gland and then degranulate.[ref] Animal studies show that hypothyroidism (low thyroid hormone levels) increases the number of mast cells by up to 4.5-fold