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Contributed The total value of the worlds top 10 most valuable tobacco brands has decreased by 6 percent, with eight out of 10 brands experiencing a decline in brand value this year, according to the latest ranking by Brand Finance, a leading brand valuation consultancy

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Nicotine is not a conventional carcinogen, but was able to induce the secretion of growth factors, resulting in the activation of Raf, Akt or PKC pathways to promote the growth of various epithelial or cancer cells (Rakowicz-Szulczynska et al, 1994