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The insulin-induced increased rate of cancer cell replication also works to the advantage of the patient, since most chemotherapeutic agents destroy preferentially those cells that are undergoing subdivision/replication

An augmented drug efflux, alteration of the molecular target, increased repair of drug-induced DNA damage, activation/suppression of signaling pathways leading to an upregulation of survival molecules and avoidance of apoptosis have been reported to be the most prominent reasons of tumor cell recalcitrance against chemotherapy (Baguley, 2010

Nat Rev Immunol (2002) 2(12):95764

The BBB is permeable to hydrophobic molecules and utilizes active transport to move ions, glucose, and other critical molecules across the membrane