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Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss

It is sold as a research chemical NNMT inhibition has broad implications : NNMT is involved in multiple metabolic pathways beyond NAD+, including methylation balance, polyamine metabolism, and one-carbon metabolism

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