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With that patented strain, 22nd Century subsequently created a series of very low nicotine content cigarette products called SPECTRUM that were exclusively provided to academic research institutions for use in clinical studies to assess the physiological and psychological effects of nicotine reduction in heavy smokers

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Van den Bosch and his team decided to continue with their study, but to publish an article in the British Medical Journal (BMJ) about the unfortunate course of events, he said