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Divergent results from research on animals suggest that the impact of folate on neoplasia varies depending on the animal and tumor model, the kind, time, amount, and duration of the carcinogen application, the stage of carcinogenesis, and the amount and type of folate given

In past clinical trials, Sekhar provided GlyNAC to small groups of people to correct a nutritional deficiency, and produced encouraging evidence supporting further studies of the value of this approach to restoring mitochondrial function in clinical trials

A high-throughput screening of synthetic compounds aimed at identifying substances capable of eliminating tumor cells led to the discovery of erastin, a compound exhibiting RAS-selective activity ( Table 2 )

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