This process, called central sensitization, involves neuroinflammation, specifically activation of microglial cells in the brain and spinal cord
Dysregulated iron metabolism is a key pathogenic feature of LN (213), and emerging evidence links these disturbances to ferroptosis (214)an iron-dependent cell death driven by lipid peroxidation, distinct from apoptosis/necrosis ( 3.5.1 CD4 T-cell iron dyshomeostasis drives SLE/LN Iron overload promotes pathogenic T-cell differentiation and accelerates disease in lupus-prone models (215): 1) In MRL/MpJ-Fas (lpr)/J (MRL/lpr) mice, iron overload expands T follicular helper (Tfh) cells, germinal center (GC) B cells, and pro-inflammatory cytokine-secreting CD4 T cells
Current human evidence relies primarily on anecdotal reports from athletes, bodybuilders, and biohacking communities
Interestingly, in ferroptosis research, ibuprofen has been shown to downregulate the Nrf2 signaling pathway, thereby inducing ferroptosis in glioblastoma cells (Wang Y